Clinical Studies

Zhonghua Yi: Curative Effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes:a clinical study.  87(38):2706-9, 2007

Ruessmann HJ: Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients.  J Diabetes Complications. 23(3):174-7, 2009

Bell David: Metformin-induced Vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J 103(3): 265-267, 2010

Smith RG: Painful Diabetic Peripheral Neuropathy. J Am Podiatric Med Assoc 97: 394, 2007

Attal N, Bouhassira D: Mechanisms of pain in peripheral neuropathy. Acta Neurol Scand Suppl 173: 12, 1999

The Diabetes Control and Complications Trial Research Group.  The effect of intensive diabetes therapy on the development and progression of neuropathy, Ann Intern Med 122: 561, 1995

Halat KM, Dennehy CE.  Botanicals and dietary supplements in diabetic peripheral neuropathy. J Am Board Fam Pract. 16: 47, 2003

NIH State-Of-The-Science Conference Statement on Multivitamin/Mineral Supplements and Chronic Disease Prevention. NIH Consensus and State-Of-The-Science Statements 23, (2): May 15-17, 2006

Nagamatsu M, Nickander KK, Schmelzer JD, et al.  Lipoic acid improves blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 16: 1160, 1995

Low PA, Nickander KK, Tritschler HJ. The roles of oxidative stress and antioxidant treatment in experimental diabetic neuropathy.  Diabetes 46: S38, 1997

Reljanovic M, Reichel G, Rett K, et al. Treatment of diabetic polyneuropathy with antioxidant thioctic acid (alpha lipoic acid): a two-year-multi-center randomized double blind placebo-controlled trial (Aladin II).  Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res 31: 171, 1999

 Ruhnau KJ, Meissner HP, Finn JR, et al.  Effects of 3-week oral treatment with antioxidant thioctic acid (alpha lipoic acid) in symptomatic diabetic polyneuropathy.  Diabet Med16: 1040, 1999

Berrone E, Beltramo E, Solimine C, et al. Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose. J Biol Chem 281: 9307, 2006

Stracke H, Gaus W, Achenbach U, et al.  Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomized, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 116: 600, 2008

McCan YJ, Davis RF. Serum pyridoxal concentrations in patients with diabetic neuropathy. Aust NZ J Med 8: 259, 1978

Jones CL, Gonzalez V. Pyridoxine deficiency: a new factor in diabetic neuropathy. J Am Podiatry Assoc. 68: 646, 1978

Tutuncu NB, Bayraktar M, Varli K.  Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: a preliminary study. Diabetes Care 11: 1915, 1998